Rx · Prescription required
Naltrexone / bupropion
Contrave®
FDA-approved for chronic weight management in adults with obesity, or overweight with a weight-related condition, as an addition to diet and exercise.
- Drug class
- Opioid antagonist + aminoketone antidepressant
- How it is given
- Extended-release tablet, twice daily
- Prescription
- Required
- Dispensed by
- DiRx Inc. · licensed pharmacy
FDA status: Contrave® and the other brand-name versions listed are FDA-approved medicines. Generic versions, where available, are FDA-approved equivalents.
Locked
Pricing is shared after you speak with our team and a licensed doctor approves treatment. Clinics see pricing after account verification.
Important safety information
Naltrexone / bupropion is a prescription medicine. It is not right for everyone: uncontrolled high blood pressure; seizure disorders or eating disorders; anyone taking opioids or opioid-containing medicines; abrupt stopping of alcohol or sedatives; use with MAO inhibitors. Tell your doctor about every condition you have and every medicine and supplement you take.
Common side effects are described below. Stop and seek care for any severe or unexpected reaction. This page is education, not medical advice; your doctor and pharmacist give the instructions for your treatment.
How to get started
- Message us on WhatsApp or call (954) 420-7747.
- Talk with a licensed doctor, who reviews your health history and decides if this medicine is right for you.
- If prescribed, our team shares pricing and a licensed pharmacy fills your order.
Plain-language guide
Naltrexone / bupropion, explained by our clinical team
What it is
Contrave® pairs two older medicines: naltrexone, used for alcohol and opioid dependence, and bupropion, an antidepressant also used to stop smoking. Together they act on the brain's hunger and reward pathways rather than on the gut.
It is a non-injectable, non-GLP-1 choice that suits people who struggle more with cravings and emotional eating than with portion size.
FDA-approved uses
- Chronic weight management in adults with a BMI of 30 or more, or 27 or more with high blood pressure, type 2 diabetes or high cholesterol
Our doctors prescribe for approved uses. Any other use is a decision made only by your doctor, for you, after evaluation.
How it is taken
Tablets are taken by mouth, increased over four weeks to two tablets in the morning and two in the evening. They should not be taken with a high-fat meal.
What to expect
Cravings and appetite usually ease within the first month. Nausea, constipation, headache and trouble sleeping are the most common side effects. If 5% of body weight has not been lost by 12 weeks on the full dose, the medicine is usually stopped.
Who should not take it
- Uncontrolled high blood pressure
- Seizure disorders or eating disorders
- Anyone taking opioids or opioid-containing medicines
- Abrupt stopping of alcohol or sedatives
- Use with MAO inhibitors
Questions we hear
Is this a stimulant?
No. Bupropion can feel activating, but Contrave® is not a controlled substance.
Will it affect my mood?
Bupropion carries a warning about mood changes and suicidal thoughts in younger adults. Tell your doctor about any history of depression.
Can I take it with a GLP-1?
Sometimes, under medical supervision. Your doctor will decide.
Real molecular structure
The molecule: Naltrexone (one of the two active ingredients)
Drag to rotate. Every atom and bond below comes from the public PubChem database of the U.S. National Institutes of Health; nothing is drawn by AI.
- Formula
- C13H18ClNO
- Molar mass
- 239.7 g/mol
- Heavy atoms
- 16
- PubChem CID
- 444 ↗
Source: PubChem, National Library of Medicine (public domain).
Watch & learn
Videos: how it works and how it is used
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Semaglutide
Ozempic® · Wegovy® · Rybelsus®FDA-approved for type 2 diabetes (Ozempic®, Rybelsus®) and for chronic weight management and cardiovascular risk reduction in eligible adults (Wegovy®).
Price after approval
Tirzepatide
Mounjaro® · Zepbound®FDA-approved for type 2 diabetes (Mounjaro®) and for chronic weight management and obstructive sleep apnea in adults with obesity (Zepbound®).
Price after approval
Liraglutide
Victoza® · Saxenda®FDA-approved for type 2 diabetes (Victoza®) and chronic weight management (Saxenda®); generic versions are now available.
Price after approval
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