Rx · Prescription required
Setmelanotide
Imcivree®
FDA-approved for chronic weight management in people 2 years and older with obesity due to confirmed POMC, PCSK1 or LEPR deficiency, or Bardet-Biedl syndrome.
- Drug class
- Melanocortin-4 receptor agonist
- How it is given
- Once-daily injection
- Prescription
- Required
- Dispensed by
- DiRx Inc. · licensed pharmacy
FDA status: Imcivree® and the other brand-name versions listed are FDA-approved medicines. If your doctor prescribes a compounded version, it is prepared by a licensed pharmacy for you and is not itself FDA-approved; your doctor and pharmacist explain which version you receive. Specialist medicine: a confirmed diagnosis from a specialist is required.
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Pricing is shared after you speak with our team and a licensed doctor approves treatment. Clinics see pricing after account verification.
Important safety information
Setmelanotide is a prescription medicine. It is not right for everyone: obesity without a confirmed genetic cause; anyone without specialist genetic evaluation. Tell your doctor about every condition you have and every medicine and supplement you take.
Common side effects are described below. Stop and seek care for any severe or unexpected reaction. This page is education, not medical advice; your doctor and pharmacist give the instructions for your treatment.
How to get started
- Message us on WhatsApp or call (954) 420-7747.
- Talk with a licensed doctor, who reviews your health history and decides if this medicine is right for you.
- If prescribed, our team shares pricing and a licensed pharmacy fills your order.
Plain-language guide
Setmelanotide, explained by our clinical team
What it is
Setmelanotide treats rare genetic forms of obesity in which the brain's satiety signaling is broken. It restores activity at the MC4 receptor, the pathway those genetic variants interrupt.
This is a specialist medicine: a confirmed genetic diagnosis is required, and treatment is managed with the patient's genetics or obesity specialist. We list it for completeness and can help coordinate.
FDA-approved uses
- Obesity caused by confirmed POMC, PCSK1 or LEPR deficiency
- Obesity in Bardet-Biedl syndrome
Our doctors prescribe for approved uses. Any other use is a decision made only by your doctor, for you, after evaluation.
How it is taken
A daily injection under the skin, started at a low dose and raised over about two weeks under specialist supervision.
What to expect
Reduced hunger within weeks for responders. Darkening of skin and moles, injection-site reactions and nausea are common. Mood is monitored during treatment.
Who should not take it
- Obesity without a confirmed genetic cause
- Anyone without specialist genetic evaluation
Questions we hear
Can I get this for ordinary weight loss?
No. It is approved only for specific genetic conditions.
Why does skin darken?
The MC4 pathway shares signaling with pigment cells; the effect is expected and monitored.
How is the diagnosis confirmed?
Through genetic testing arranged by a specialist.
Real molecular structure
The molecule: Setmelanotide
Drag to rotate. Every atom and bond below comes from the public PubChem database of the U.S. National Institutes of Health; nothing is drawn by AI.
- Formula
- C49H68N18O9S2
- Molar mass
- 1,117.3 g/mol
- Heavy atoms
- 146
- PubChem CID
- 11993702 ↗
Source: PubChem, National Library of Medicine (public domain).
Watch & learn
Videos: how it works and how it is used
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