Guide

GLP-1 side effects: what's common and when to call your doctor

Common side effects of GLP-1 medicines and the warning signs that mean you should call your doctor or get emergency care.

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Updated 2026-09-29 · Reviewed for accuracy by the EKO Labs team. Educational only; not medical advice.

Most side effects of GLP-1GLP-1 (glucagon-like peptide-1) a hormone the gut releases after eating. It helps release insulin, slows stomach emptying and signals fullness. medicines are mild and affect the stomach. Some are rare but serious. Knowing the difference helps you act early.

Common side effects

  • Nausea, especially at the start or after a dose increase
  • Diarrhea or constipation
  • Vomiting
  • Reduced appetite
  • Stomach discomfort or bloating

Call your doctor if you have

  • Vomiting or diarrhea that does not stop, or signs of dehydration
  • Pain in the upper right belly, fever or yellow skin or eyes (possible gallbladder problems)
  • A lump or swelling in the neck, trouble swallowing or hoarseness
  • Changes in vision if you have diabetes

Get emergency care for

  • Severe stomach pain that may spread to your back (possible pancreatitisPancreatitis inflammation of the pancreas. Severe stomach pain that does not go away needs urgent care.)
  • Signs of a serious allergic reaction: swelling of the face or throat, trouble breathing

In an emergency, call 911. This guide is not a complete list. Always read the medication guide that comes with your prescription.

Have questions about your situation?

Talk to our team. A licensed doctor makes every medical decision.

Treatments mentioned in this guide

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