Rx · Prescription required
Doxepin (low dose)
Silenor®
FDA-approved at 3 mg and 6 mg for insomnia characterized by difficulty staying asleep. Not a controlled substance.
- Drug class
- Tricyclic, histamine H1 antagonist at low dose
- How it is given
- Tablet at bedtime
- Prescription
- Required
- Dispensed by
- DiRx Inc. · licensed pharmacy
FDA status: Silenor® and the other brand-name versions listed are FDA-approved medicines. Generic versions, where available, are FDA-approved equivalents.
Locked
Pricing is shared after you speak with our team and a licensed doctor approves treatment. Clinics see pricing after account verification.
Important safety information
Doxepin (low dose) is a prescription medicine. It is not right for everyone: untreated narrow-angle glaucoma or urinary retention; use with MAO inhibitors; severe sleep apnea. Tell your doctor about every condition you have and every medicine and supplement you take.
Common side effects are described below. Stop and seek care for any severe or unexpected reaction. This page is education, not medical advice; your doctor and pharmacist give the instructions for your treatment.
How to get started
- Message us on WhatsApp or call (954) 420-7747.
- Talk with a licensed doctor, who reviews your health history and decides if this medicine is right for you.
- If prescribed, our team shares pricing and a licensed pharmacy fills your order.
Plain-language guide
Doxepin (low dose), explained by our clinical team
What it is
At these very low doses, doxepin acts almost purely as a histamine blocker in the brain, which helps people stay asleep through the night without the weight of a full antidepressant dose.
It is a good choice for middle-of-the-night and early-morning waking, especially in older adults, and it is not a controlled substance.
FDA-approved uses
- Insomnia with difficulty maintaining sleep
Our doctors prescribe for approved uses. Any other use is a decision made only by your doctor, for you, after evaluation.
How it is taken
One tablet within 30 minutes of bedtime, at least three hours after a meal, only when a full night of sleep is possible.
What to expect
Fewer awakenings and more total sleep; mild next-day drowsiness is possible in the first days.
Who should not take it
- Untreated narrow-angle glaucoma or urinary retention
- Use with MAO inhibitors
- Severe sleep apnea
Questions we hear
Is 6 mg an antidepressant dose?
No. Antidepressant doses are 25 to 300 mg; this is a different use entirely.
Can it be combined with ramelteon?
Sometimes, when both falling and staying asleep are problems; your doctor decides.
Is it safe long term?
It has been studied for long-term use in insomnia.
Real molecular structure
The molecule: Doxepin (low dose)
Drag to rotate. Every atom and bond below comes from the public PubChem database of the U.S. National Institutes of Health; nothing is drawn by AI.
- Formula
- C19H21NO
- Molar mass
- 279.4 g/mol
- Heavy atoms
- 21
- PubChem CID
- 3158 ↗
Source: PubChem, National Library of Medicine (public domain).
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Ramelteon
Rozerem®FDA-approved for insomnia characterized by difficulty falling asleep. Not a controlled substance.
Price after approval
Suvorexant
Belsomra®FDA-approved for insomnia with difficulty falling asleep and/or staying asleep.
Price after approval
Semaglutide
Ozempic® · Wegovy® · Rybelsus®FDA-approved for type 2 diabetes (Ozempic®, Rybelsus®) and for chronic weight management and cardiovascular risk reduction in eligible adults (Wegovy®).
Price after approval
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