Rx · Prescription required

Bupropion SR

Zyban® · Wellbutrin SR®

FDA-approved as an aid to smoking cessation (Zyban®) and for major depressive disorder (Wellbutrin®).

Drug class: Aminoketone antidepressant
How it is given: Tablet, twice daily
Prescription: Required
Dispensed by: DiRx Inc. · licensed pharmacy

FDA status: Zyban® and the other brand-name versions listed are FDA-approved medicines. Generic versions, where available, are FDA-approved equivalents.

Locked

Pricing is shared after you speak with our team and a licensed doctor approves treatment. Clinics see pricing after account verification.

Talk to our team Call (954) 420-7747

Important safety information

Bupropion SR is a prescription medicine. It is not right for everyone: seizure disorders, eating disorders or abrupt withdrawal from alcohol or sedatives; mAO inhibitors within 14 days; anyone already taking another bupropion product. Tell your doctor about every condition you have and every medicine and supplement you take.

Common side effects are described below. Stop and seek care for any severe or unexpected reaction. This page is education, not medical advice; your doctor and pharmacist give the instructions for your treatment.

How to get started

Message us on WhatsApp or call (954) 420-7747.
Talk with a licensed doctor, who reviews your health history and decides if this medicine is right for you.
If prescribed, our team shares pricing and a licensed pharmacy fills your order.

Plain-language guide

Bupropion SR, explained by our clinical team

What it is

Bupropion reduces nicotine craving and withdrawal irritability by acting on dopamine and noradrenaline. It is a non-nicotine, non-controlled option that also treats depression, which often travels with smoking.

It is the same molecule found in Contrave®, so our doctors check for overlaps before prescribing.

FDA-approved uses

Aid to smoking cessation
Major depressive disorder

Our doctors prescribe for approved uses. Any other use is a decision made only by your doctor, for you, after evaluation.

How it is taken

One tablet daily for three days, then one twice daily at least eight hours apart, starting one to two weeks before the quit date, for 7 to 12 weeks.

What to expect

Less craving and irritability; dry mouth, insomnia and headache are the common side effects. Seizure risk rises with higher doses or certain conditions.

Who should not take it

Seizure disorders, eating disorders or abrupt withdrawal from alcohol or sedatives
MAO inhibitors within 14 days
Anyone already taking another bupropion product

Questions we hear

Is it as effective as varenicline?

Somewhat less, but a good option when varenicline is not suitable.

Can it be combined with varenicline?

Sometimes, for heavy smokers, under medical supervision.

Will it help my mood?

It is an approved antidepressant, so often yes.

Real molecular structure

The molecule: Bupropion SR

Drag to rotate. Every atom and bond below comes from the public PubChem database of the U.S. National Institutes of Health; nothing is drawn by AI.

3D conformer — drag to rotateCNOS

Formula: C13H18ClNO
Molar mass: 239.7 g/mol
Heavy atoms: 16
PubChem CID: 444 ↗

Source: PubChem, National Library of Medicine (public domain).

Watch & learn

Videos: how it works and how it is used

Independent videos from doctors, hospitals and health educators on YouTube. They are for general education; your doctor gives the instructions for your treatment.

How to use