Rx · Prescription required

Ondansetron

Zofran® · Zofran ODT®

FDA-approved to prevent nausea and vomiting caused by chemotherapy, radiation and surgery.

Drug class: 5-HT3 receptor antagonist (antiemetic)
How it is given: Tablet or dissolving tablet
Prescription: Required
Dispensed by: DiRx Inc. · licensed pharmacy

FDA status: Zofran® and the other brand-name versions listed are FDA-approved medicines. Generic versions, where available, are FDA-approved equivalents.

Locked

Pricing is shared after you speak with our team and a licensed doctor approves treatment. Clinics see pricing after account verification.

Talk to our team Call (954) 420-7747

Important safety information

Ondansetron is a prescription medicine. It is not right for everyone: use with apomorphine; congenital long QT syndrome; serotonergic drug combinations without review. Tell your doctor about every condition you have and every medicine and supplement you take.

Common side effects are described below. Stop and seek care for any severe or unexpected reaction. This page is education, not medical advice; your doctor and pharmacist give the instructions for your treatment.

How to get started

Message us on WhatsApp or call (954) 420-7747.
Talk with a licensed doctor, who reviews your health history and decides if this medicine is right for you.
If prescribed, our team shares pricing and a licensed pharmacy fills your order.

Plain-language guide

Ondansetron, explained by our clinical team

What it is

Ondansetron blocks serotonin signals in the gut and brain that trigger vomiting. It is non-sedating and comes as a tablet that dissolves on the tongue, which matters when keeping anything down is hard.

Our doctors may prescribe it when nausea is expected from a planned treatment; any other use is an individual medical judgment, not a standing offer.

FDA-approved uses

Prevention of nausea and vomiting from chemotherapy and radiotherapy
Prevention of postoperative nausea and vomiting

Our doctors prescribe for approved uses. Any other use is a decision made only by your doctor, for you, after evaluation.

How it is taken

Usually one dose 30 minutes before the triggering treatment, then every 8 to 12 hours as directed, for a limited number of days.

What to expect

Markedly less nausea; headache, constipation and fatigue are common. The heart rhythm effect (QT prolongation) is monitored in people at risk.

Who should not take it

Use with apomorphine
Congenital long QT syndrome
Serotonergic drug combinations without review

Questions we hear

Can I use it for GLP-1 nausea?

That is an off-label use; your doctor will decide what is appropriate for you.

Does it make me sleepy?

No, it is not sedating.

Is it safe in pregnancy?

Discuss with your obstetrician; it is sometimes used after other options.

Real molecular structure

The molecule: Ondansetron

Drag to rotate. Every atom and bond below comes from the public PubChem database of the U.S. National Institutes of Health; nothing is drawn by AI.

3D conformer — drag to rotateCNOS

Formula: C18H19N3O
Molar mass: 293.4 g/mol
Heavy atoms: 22
PubChem CID: 4595 ↗

Source: PubChem, National Library of Medicine (public domain).

Watch & learn

Videos: how it works and how it is used

Independent videos from doctors, hospitals and health educators on YouTube. They are for general education; your doctor gives the instructions for your treatment.

How to use